ATTENTION

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THE EFFECT OF GENDER ON RATE OF EMERGENCE FROM TOTAL INTRAVENOUS ANAESTHESIA IN OBAFEMI AWOLOWO UNIVERSITY TEACHING HOSPITALS COMPLEX, ILE-IFE.

ABSTRACT

BACKGROUND: The rate of emergence from general anaesthesia has

always been an interesting subject to the anaesthetist. The effect of

gender as an independent factor influencing recovery is known to be

masked by several other factors including drug dosage, time of

administration, age, liver and renal diseases. This double blinded

study was carried out to ascertain the role gender plays in emergence

from Intravenous Propofol general anaesthesia.

AIMS AND OBJECTIVES: This study was undertaken to ascertain

the rate of emergence from Intravenous Propofol general anaesthesia

among male and female elective general surgery patients and to

determine any significant difference in the rate of emergence from

the effects of Intravenous Propofol general anaesthesia between the

sexes. It was also carried out to identify other possible modifiable

factors that may be responsible for the rate of emergence from

Intravenous Propofol general anaesthesia among both sexes.

METHODOLOGY: One hundred and twenty ASA I and II patients,

aged 18-70 years undergoing elective general surgical procedures

under general anaesthesia lasting between 60 to 120 minutes (60

males and 60 females) were included in the study. The rate of

recovery was observed continuously after the termination of

anaesthesia. Wake up events were timed and recorded by

anaesthetists not involved with administration of the anaesthesia.

RESULTS: The time from end of anaesthesia to spontaneous eye

opening was 5.56±1.56mins for women versus 9.36±2.35mins in

men(P=0.000), eye opening to verbal commands was 4.58±1.52mins

for women versus 8.62±2.89mins in men(P=0.000) , responding to

verbal commands was 6.19±1.68mins for women versus

10.22±2.80mins in men(P=0.000), moving limbs to adequate muscle

power was 7.14±1.66mins for women versus

11.05±2.32mins(P=0.000) and time of extubation was

7.92±1.77mins for women versus 14.07±16.29mins(P=0.005) in

men. Premenopausal women also emerged faster than

postmenopausal women.

CONCLUSION: Gender is an important factor for emergence from the

effects of Propofol general anaesthesia as women emerged faster than men from Propofol general anaesthesia provided by TIVA.

Pharmacokinetic and pharmacodynamic factors as well as hormonal

influence may explain this difference in wake up time a between males and females.

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Account Number: 0046579864

Bank: GTBank.

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Account Number: 3139283609

Bank: FIRST BANK

FOR MORE INFORMATION, CALL:

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