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HEPATOPROTECTIVE POTENTIAL OF RUSSELIA EQUISETIFORMIS PLANT EXTRACT ON DRUG-INDUCED HEPATOTOXICITY IN EXPERIMENTAL MODELS<\/strong><\/p>\n\n\n\n
Abstract<\/p>\n\n\n\n
Background: A large number of herbal medicines are widely in-use to offer relief from hepatic injury,<\/p>\n\n\n\n
although attempts are still ongoing globally to get scientific proofs for these orthodox remedies, there is<\/p>\n\n\n\n
still paucity of data on Russelia equisetiformes. There are solitary reports of anti-inflammatory, analgesic,<\/p>\n\n\n\n
and antinociceptive properties. Meanwhile, inflammation is a hallmark of hepatic injury. Further study may<\/p>\n\n\n\n
pave way for next generation hepatoprotective medication.<\/p>\n\n\n\n
Methods: The experimental animals were grouped into five (5), with six animals each. Groups 3, 4 and 5<\/p>\n\n\n\n
were orally pretreated with the extracts for 7 days at doses of 100, 200 and 400 mg\/kg, while groups 1 and<\/p>\n\n\n\n
2 served as normal (negative) and paracetamol-induced (PCM-induced;positive) controls. Liver damage<\/p>\n\n\n\n
was induced on the 8th day using 2000 mg\/kg of paracetamol. Liver enzymes such as alanine amino<\/p>\n\n\n\n
transaminase (ALT) aspartate amino transaminase (AST) and alkaline phosphatase (ALP), along with other<\/p>\n\n\n\n
liver function tests [plasma total protein (TP), albumin (ALB) and bilirubin (BIL)] were subsequently<\/p>\n\n\n\n
estimated. Liver samples were examined for histopathological changes.<\/p>\n\n\n\n
Results: Comparison of case groups with positive controls shows that levels of biomarkers such as AST,<\/p>\n\n\n\n
ALT, ALP were significantly reduced (p<\/p>\n\n\n\n
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